Crohn's disease susceptibility genes are associated with leprosy in the Vietnamese population.

نویسندگان

  • Audrey V Grant
  • Andrea Alter
  • Nguyen Thu Huong
  • Marianna Orlova
  • Nguyen Van Thuc
  • Nguyen Ngoc Ba
  • Vu Hong Thai
  • Laurent Abel
  • Erwin Schurr
  • Alexandre Alcais
چکیده

A genomewide association study in Chinese patients with leprosy detected association signals in 16 single-nucleotide polymorphisms (SNPs) belonging to 6 loci, of which 4 are related to the NOD2 signaling pathway and are Crohn's disease susceptibility loci. Here, we studied these 16 SNPs as potential leprosy susceptibility factors in 474 Vietnamese leprosy simplex families. We replicated SNPs at HLA-DR-DQ, RIPK2, CCDC122-LACC1, and NOD2 as leprosy susceptibility factors in Vietnam. These results validated the striking overlap in the genetic control of Crohn's disease and leprosy.

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عنوان ژورنال:
  • The Journal of infectious diseases

دوره 206 11  شماره 

صفحات  -

تاریخ انتشار 2012